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Title: Synthesis of symmetrically / unsymmetrically substituted bisbenzimidazolesulphides of potential pharmacological interest
Authors: Rao, S Srinivas
Mahesh, Putluru
Reddy, Ch Venkata Ramana
Dubey, P K
Keywords: 2-(1-Chloroethyl)-1-alkyl-1H-benzimidazole;2-mercapto-benzimidazole;K2CO3;Triethylamine;Bisbenzimidazolesulphides
Issue Date: May-2015
Publisher: NISCAIR-CSIR, India
Abstract: 2-(1-Chloroethyl)-1H-benzimidazole 1a on condensation with 2-mercaptobenzimidazole 2a in methanol using triethylamine as a base under reflux for 3 hr yields 2-((1-(1H-benzimidazol-2-yl)ethyl)thio)-1H-benzimidazole 3a which on alkylation using two equivalents of alkylating agent under phase transfer catalyst (PTC) conditions gives N,N1-dialkylbisbenzimidazolesulphides 3b-e. Using this synthetic strategy, N,N1-unsymmetricallydialkylbis-benzimidazolesulphides 3f-q are prepared by condensing 2-(1-chloroethyl)-1H-benzimidazole 1a with N1-alkyl-2-mercaptoben-zimidazole 2b-e to obtain 3 followed by alkylation under PTC conditions.
Page(s): 698-702
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(05) [May 2015]

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