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Title: Cytotoxic triterpenoids from Ficus pomifera Wall.
Authors: Wangkheirakpam, Sujata D
Wadawale, Amey
Leishangthem, Surendrajit S
Gurumayum, Jitendra S
Laitonjam, Warjeet S
Keywords: Ficus;Moraceae;Triterpenoid;Mo-Kα X ray crystallography;Antioxidant;Cytotoxic
Issue Date: May-2015
Publisher: NISCAIR-CSIR, India
Abstract: 3β-Acetoxyurs-12-ene 1, 3β-hydroxyurs-12-ene 2 and three other triterpenoids, 3β-hydroxyurs-12-en-27-oic acid 3, 3β-hydroxyolean-12-en-27-oic acid 4 and 3α-acetoxyolean-12-en-27-oic acid 5 have been isolated from Ficus pomifera Wall. Their chemical structures have been established by spectroscopic analysis. The structure of compound 1 is confirmed with single-crystal X-ray analysis. Compound 1 has been characterised for properties such as particle size and photoluminescence with fluorescence spectroscopy and transmission electron microscopy (TEM) for applications comparable to those of nanocomposites. The size has been characterised in the range of nanoparticles, and the compound exhibit fluorescence. Compounds 1 and 2 show cytotoxic activity in an MTT assay on human lung cancer cell line A549, exhibiting IC50 values of 15 µg/mL and 3 µg/mL, respectively.
Page(s): 676-681
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(05) [May 2015]

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