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Title: Comparative studies of synthesis of symmetric 2,6-di(benzofuran-2-yl)- 4-phenyl-pyridine derivatives via pyrylium tetrafluoroborate salt and 1,5-dione derivatives
Authors: Kumar, D B Aruna
Desai, Nivedita R
Krishnaswamy, G
Sreenivasa, S
Mahadevan, K M
Keywords: 2-Acetylbenzofuran;Symmetric;1,5-diones;Michael addition;Pyrylium tetrafluoro borate salt;Pyridine
Issue Date: Apr-2015
Publisher: NISCAIR-CSIR, India
Abstract: A comparative study for the synthesis of symmetric 2,6-di(benzofuran-2-yl)-4-phenyl-pyridine derivatives 4a-h as antibacterial agents, has been reported by two methods. Method A follows nucleophilic substitution reaction of 2,6-di (benzofuran-2-yl)-4-phenyl-pyrilium tetrafluoroborate salt derivatives 3a-h with ammonium acetate in ether at room temperature. Method B follows cyclisation reaction of 1,5-di (benzofuran-2-yl)-3-(4-substituted-aryl)-pentane-1,5-dione derivatives 2a-h with ammonium acetate in acetic acid under reflux. It has been found that method B proceeds under mild reaction condition with short reaction time and high yield when compared to method A. The structures of the newly synthesized compounds have been characterized by spectral studies.
Page(s): 538-544
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(04) [April 2015]

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