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|Title:||Azaisoflavones: Synthesis, antimicrobial evaluation and binding affinity with DNA gyrase|
Kumar, P Senthil
Perumal, P T
|Keywords:||Super acid catalysis;Azaisoflavones;Antimicrobial;Docking;DNA gyrase|
|Abstract:||Antimicrobial potency of azaisoflavones has been evaluated in vitro against nine bacterial and two fungal strains, respectively. The requisite azaisoflavones are conveniently synthesized in three steps, with the key step being the super acid catalyzed tandem reaction. The biological results reveal that out of twelve compounds screened, 3 compounds (5a, 5j and 5l) exhibited comparable activities against the standard drugs and demonstrated activities at μM concentration. In addition, molecular docking revealed that compound 5a as the most potent by showing a least binding energy of ‒5.99 kcal/mol with DNA gyrase receptor compared to other compounds.|
|Appears in Collections:||IJC-B Vol.54B(03) [March 2015]|
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