NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.06 [2007] >
IJBT Vol.06(4) [October 2007] >


Title: Genomic analysis of SNPs in breast cancer by using bioinformatics databases
Authors: Sankar, K Siva
Reddy, N Satish Chandra
Jamil, Kaiser
Mohana, Vamsy C
Keywords: SNPs
breast cancer genes
loci
DNA-repair
Pharmacogenomics
Issue Date: Oct-2007
Publisher: CSIR
IPC CodeInt.Cl.⁸ C12N15/00
Abstract: The role of single nucleotide polymorphs (SNPs) in genes that modulate or promote cancer process has not been fully understood. Hence, an attempt has been made to collect data from Entrez Genome View, Cancer Genome Anatomy Project (NCBI) and Online Mendelian Inheritance in Man (OMIM) databases for enumerating and locating the number of SNPs in the loci of various chromosomes involved in cancerous and non-cancerous breast tissue. DNA methylation and mutations in the hotspots of the proto-oncogenes leading to formation of carcinomas in the breast tissue have been identified and discussed. Transition in the hotspots may reflect endogenous mutations and sporadic loss of DNA repair factors. This has been related to various molecular mechanisms and gene expression variations. SNPs also play important roles in conformational changes in proteins, resulting in non-functional or truncated proteins at the post-translational levels. Although SNPs in introns may not directly result in a change in function of a gene, they may be taken as biomarkers to locate the site near genes. SNPs technology has enormous potential in clinical research and pharmacogenomics. Hence, effort has been to understand the basic difference between candidate and validated SNPs and their significance in carcinogenesis or predisposition.
Page(s): 456-462
ISSN: 0972-5849
Source:IJBT Vol.06(4) [October 2007]

Files in This Item:

File Description SizeFormat
IJBT 6(4) 456-462.pdf239.25 kBAdobe PDFView/Open
 Current Page Visits: 1273 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 586995 since 06-Feb-2009  Last updated on 18-Sep-2014Webmaster: nopr@niscair.res.in