Please use this identifier to cite or link to this item:
Title: Genomic analysis of SNPs in breast cancer by using bioinformatics databases
Authors: Sankar, K Siva
Reddy, N Satish Chandra
Jamil, Kaiser
Mohana, Vamsy C
Keywords: SNPs
breast cancer genes
Issue Date: Oct-2007
Publisher: CSIR
Series/Report no.: Int.Cl.⁸ C12N15/00
Abstract: The role of single nucleotide polymorphs (SNPs) in genes that modulate or promote cancer process has not been fully understood. Hence, an attempt has been made to collect data from Entrez Genome View, Cancer Genome Anatomy Project (NCBI) and Online Mendelian Inheritance in Man (OMIM) databases for enumerating and locating the number of SNPs in the loci of various chromosomes involved in cancerous and non-cancerous breast tissue. DNA methylation and mutations in the hotspots of the proto-oncogenes leading to formation of carcinomas in the breast tissue have been identified and discussed. Transition in the hotspots may reflect endogenous mutations and sporadic loss of DNA repair factors. This has been related to various molecular mechanisms and gene expression variations. SNPs also play important roles in conformational changes in proteins, resulting in non-functional or truncated proteins at the post-translational levels. Although SNPs in introns may not directly result in a change in function of a gene, they may be taken as biomarkers to locate the site near genes. SNPs technology has enormous potential in clinical research and pharmacogenomics. Hence, effort has been to understand the basic difference between candidate and validated SNPs and their significance in carcinogenesis or predisposition.
Description: 456-462
ISSN: 0972-5849
Appears in Collections:IJBT Vol.06(4) [October 2007]

Files in This Item:
File Description SizeFormat 
IJBT 6(4) 456-462.pdf239.25 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.