Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/30834
Title: Improved microwave induced syntheses and reactions of 2-aryl-3-(3-aryl-3oxo-propen-1-yl)-indoles with thiourea and hydrazine derivatives
Authors: Dandia, Anshu
Rani, Babita
Saha, Mitali
Issue Date: May-1998
Publisher: NISCAIR-CSIR, India
Abstract: The potential of domestic microwave oven has been utilized to accelerate the reactions of 2-aryl-3-(3aryl- 3-oxo-propen-1-yl)-indoles (III) with hydrazine hydrate/phenyl hydrazine and thiourea, to obtain 2aryl- 3-[3-aryl-pyrazol-5-yl]-indoles (IV) and 2-aryl-3-[4-aryl-5, 6-dihydro-2(1H)-thioxopyrimidine-6yl]- indole (V). The former indolyl chalcones (III) have been synthesized by the condensation of 2-aryl-1H- indole-3-carboxaldehyde (I) and fluorinated acetophenones (II) in the presence of sodium hydroxide in open borosil glass vessels under microwave irradiation, using ethanol as energy transfer medium. The results obtained demonstrate the versatility of the process as considerable reaction rate enhancement has been observed bringing down the reaction time from hours to seconds, along with improved yields. All synthesized compounds have been characterized on the basis of elemental analyses, IR, 1H NMR, 19F NMR and mass spectral studies.
Page(s): 159-162
URI: http://hdl.handle.net/123456789/30834
ISSN: 0975-0991 (Online); 0971-457X (Print)
Appears in Collections:IJCT Vol.05(3) [May 1998]

Files in This Item:
File Description SizeFormat 
IJCT 5(3) 159-162.pdf258.22 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.