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Title: Human granulocyte-macrophage colony-stimulating factor : The protein and its current & emerging applications
Authors: Ghosh, Prasanta K
Bhardwaj, Devesh
Karnik, Rucha
Keywords: GM-CSF
T-cell induction
cytokines applications
GM-CSF applications
Crohn’s disease
Issue Date: Oct-2007
Publisher: CSIR
IPC CodeInt. Cl.⁸ C12N15/09, 15/10, 15/11
Abstract: Blood cells under a variety of conditions produce cytokines which regulate their proliferation, communication and functioning. The granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor mainly responsible for the proliferation of granulocyte-s and macrophages. It is a molecule of immense therapeutic interest due to its wide-ranging actions on immune cells. Recombinant human GM-CSF has been expressed, purified and characterized. It has diverse biological manifestations, which has led to its being explored for use in cancer therapy, AIDS therapy, as a vaccine adjuvant, in certain types of wound healing, promotion of collateral growth of coronary artery, usefulness in treating Crohn’s disease symptoms and in the management of a host of viral, bacterial and fungal infections. Newer therapeutic applications are also being unveiled. The physico-chemical as well as the biological features and the applications (current and emerging) of GM-CSF are discussed.
Page(s): 435-448
ISSN: 0972-5849
Source:IJBT Vol.06(4) [October 2007]

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