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http://nopr.niscair.res.in/handle/123456789/3080
Title: | Human granulocyte-macrophage colony-stimulating factor : The protein and its current & emerging applications |
Authors: | Ghosh, Prasanta K Bhardwaj, Devesh Karnik, Rucha |
Keywords: | GM-CSF;cytokines;T-cell induction;cytokines applications;GM-CSF applications;Crohn’s disease |
Issue Date: | Oct-2007 |
Publisher: | CSIR |
IPC Code: | Int. Cl.⁸ C12N15/09, 15/10, 15/11 |
Abstract: | Blood cells under a variety of conditions produce cytokines which regulate their proliferation, communication and functioning. The granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor mainly responsible for the proliferation of granulocyte-s and macrophages. It is a molecule of immense therapeutic interest due to its wide-ranging actions on immune cells. Recombinant human GM-CSF has been expressed, purified and characterized. It has diverse biological manifestations, which has led to its being explored for use in cancer therapy, AIDS therapy, as a vaccine adjuvant, in certain types of wound healing, promotion of collateral growth of coronary artery, usefulness in treating Crohn’s disease symptoms and in the management of a host of viral, bacterial and fungal infections. Newer therapeutic applications are also being unveiled. The physico-chemical as well as the biological features and the applications (current and emerging) of GM-CSF are discussed. |
Page(s): | 435-448 |
URI: | http://hdl.handle.net/123456789/3080 |
ISSN: | 0972-5849 |
Appears in Collections: | IJBT Vol.06(4) [October 2007] |
Files in This Item:
File | Description | Size | Format | |
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IJBT 6(4) 435-448.pdf | 595.76 kB | Adobe PDF | View/Open |
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