NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.06 [2007] >
IJBT Vol.06(4) [October 2007] >


Title: Human granulocyte-macrophage colony-stimulating factor : The protein and its current & emerging applications
Authors: Ghosh, Prasanta K
Bhardwaj, Devesh
Karnik, Rucha
Keywords: GM-CSF
cytokines
T-cell induction
cytokines applications
GM-CSF applications
Crohn’s disease
Issue Date: Oct-2007
Publisher: CSIR
IPC CodeInt. Cl.⁸ C12N15/09, 15/10, 15/11
Abstract: Blood cells under a variety of conditions produce cytokines which regulate their proliferation, communication and functioning. The granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic growth factor mainly responsible for the proliferation of granulocyte-s and macrophages. It is a molecule of immense therapeutic interest due to its wide-ranging actions on immune cells. Recombinant human GM-CSF has been expressed, purified and characterized. It has diverse biological manifestations, which has led to its being explored for use in cancer therapy, AIDS therapy, as a vaccine adjuvant, in certain types of wound healing, promotion of collateral growth of coronary artery, usefulness in treating Crohn’s disease symptoms and in the management of a host of viral, bacterial and fungal infections. Newer therapeutic applications are also being unveiled. The physico-chemical as well as the biological features and the applications (current and emerging) of GM-CSF are discussed.
Page(s): 435-448
ISSN: 0972-5849
Source:IJBT Vol.06(4) [October 2007]

Files in This Item:

File Description SizeFormat
IJBT 6(4) 435-448.pdf595.76 kBAdobe PDFView/Open
 Current Page Visits: 1051 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 556423 since 06-Feb-2009  Last updated on 15-Jul-2014Webmaster: nopr@niscair.res.in