Please use this identifier to cite or link to this item:
|Title:||3,5-Bis(arylmethylene)-4-piperidone derivatives as novel anticancer agents|
Duffield, Katherine M
|Keywords:||Piperidone derivatives;Anticancer agents;Cytotoxic;Thiolation;Topoisomerase II;Green chemistry|
|IPC Code:||Int. Cl.8 C07D|
|Abstract:||3,5-Bis(arylmethylene)-4-piperidone derivatives have emerged as novel clusters of cytotoxic agents. The focus of the current research has been to tine tune the biological activity of these compounds by rational alteration of substituents on this pharmacophore to increase potency and selectivity. These compounds arc presumed to bc devoid of gcnctoxicity and act by selective thiolation of proteins. Anticancer behavior of nine clusters of 3,5-bis(arylmethylene)-4-piperidone derivatives have been reviewed here with emphasis on their chemistry, cytoxicity and quantitative structure-activity relationship studies.|
|Appears in Collections:||IJC-B Vol.45B(10) [October 2006]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.