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Title: 3,5-Bis(arylmethylene)-4-piperidone derivatives as novel anticancer agents
Authors: Jha, Amitabh
Duffield, Katherine M
Keywords: Piperidone derivatives;Anticancer agents;Cytotoxic;Thiolation;Topoisomerase II;Green chemistry
Issue Date: Oct-2006
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8 C07D
Abstract: 3,5-Bis(arylmethylene)-4-piperidone derivatives have emerged as novel clusters of cytotoxic agents. The focus of the current research has been to tine tune the biological activity of these compounds by rational alteration of substituents on this pharmacophore to increase potency and selectivity. These compounds arc presumed to bc devoid of gcnctoxicity and act by selective thiolation of proteins. Anticancer behavior of nine clusters of 3,5-bis(arylmethylene)-4-piperidone derivatives have been reviewed here with emphasis on their chemistry, cytoxicity and quantitative structure-activity relationship studies.
Page(s): 2313-2320
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.45B(10) [October 2006]

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