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IJEB Vol.47(02) [February 2009] >


Title: Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action
Authors: Preethi, Korengath Chandran
Kuttan, Girija
Kuttan, Ramadasan
Keywords: Anti-inflammatory agents
Calendula officinalis
Cyclooxygenase-2
Proinflammatory cytokines
Issue Date: Jan-2009
Publisher: CSIR
Abstract: Calendula officinalis flower extract possessed significant anti-inflammatory activity against carrageenan and dextran-induced acute paw edema. Oral administration of 250 and 500 mg/kg body weight Calendula extract produced significant inhibition (50.6 and 65.9% respectively) in paw edema of animals induced by carrageenan and 41.9 and 42.4% respectively with inflammation produced by dextran. In chronic anti-inflammatory model using formalin, administration of 250 and 500 mg/kg body weight Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls. TNF-α production by macrophage culture treated with lipopolysaccharide (LPS) was found to be significantly inhibited by Calendula extract. Moreover, increased levels of proinflammatory cytokines IL-1β, IL-6, TNF-⍺ and IFN-ϒ and acute phase protein, C- reactive protein (CRP) in mice produced by LPS injection were inhibited significantly by the extract. LPS induced cyclooxygenase-2 (Cox-2) levels in mice spleen were also found to be inhibited by extract treatment. The results showed that potent anti-inflammatory response of C. officinalis extract may be mediated by the inhibition of proinflammatory cytokines and Cox-2 and subsequent prostaglandin synthesis.
Page(s): 113-120
ISSN: 0019-5189
Source:IJEB Vol.47(02) [February 2009]

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