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http://nopr.niscair.res.in/handle/123456789/3072
Title: | Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action |
Authors: | Preethi, Korengath Chandran Kuttan, Girija Kuttan, Ramadasan |
Keywords: | Anti-inflammatory agents;Calendula officinalis;Cyclooxygenase-2;Proinflammatory cytokines |
Issue Date: | Jan-2009 |
Publisher: | CSIR |
Abstract: | Calendula officinalis flower extract possessed significant anti-inflammatory activity against carrageenan and dextran-induced acute paw edema. Oral administration of 250 and 500 mg/kg body weight Calendula extract produced significant inhibition (50.6 and 65.9% respectively) in paw edema of animals induced by carrageenan and 41.9 and 42.4% respectively with inflammation produced by dextran. In chronic anti-inflammatory model using formalin, administration of 250 and 500 mg/kg body weight Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls. TNF-α production by macrophage culture treated with lipopolysaccharide (LPS) was found to be significantly inhibited by Calendula extract. Moreover, increased levels of proinflammatory cytokines IL-1β, IL-6, TNF-⍺ and IFN-ϒ and acute phase protein, C- reactive protein (CRP) in mice produced by LPS injection were inhibited significantly by the extract. LPS induced cyclooxygenase-2 (Cox-2) levels in mice spleen were also found to be inhibited by extract treatment. The results showed that potent anti-inflammatory response of C. officinalis extract may be mediated by the inhibition of proinflammatory cytokines and Cox-2 and subsequent prostaglandin synthesis. |
Page(s): | 113-120 |
URI: | http://hdl.handle.net/123456789/3072 |
ISSN: | 0019-5189 |
Appears in Collections: | IJEB Vol.47(02) [February 2009] |
Files in This Item:
File | Description | Size | Format | |
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IJEB 47(2) 113-120.pdf | 448.05 kB | Adobe PDF | View/Open |
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