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|Title:||Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action|
|Authors:||Preethi, Korengath Chandran|
|Keywords:||Anti-inflammatory agents;Calendula officinalis;Cyclooxygenase-2;Proinflammatory cytokines|
|Abstract:||Calendula officinalis flower extract possessed significant anti-inflammatory activity against carrageenan and dextran-induced acute paw edema. Oral administration of 250 and 500 mg/kg body weight Calendula extract produced significant inhibition (50.6 and 65.9% respectively) in paw edema of animals induced by carrageenan and 41.9 and 42.4% respectively with inflammation produced by dextran. In chronic anti-inflammatory model using formalin, administration of 250 and 500 mg/kg body weight Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls. TNF-α production by macrophage culture treated with lipopolysaccharide (LPS) was found to be significantly inhibited by Calendula extract. Moreover, increased levels of proinflammatory cytokines IL-1β, IL-6, TNF-⍺ and IFN-ϒ and acute phase protein, C- reactive protein (CRP) in mice produced by LPS injection were inhibited significantly by the extract. LPS induced cyclooxygenase-2 (Cox-2) levels in mice spleen were also found to be inhibited by extract treatment. The results showed that potent anti-inflammatory response of C. officinalis extract may be mediated by the inhibition of proinflammatory cytokines and Cox-2 and subsequent prostaglandin synthesis.|
|Appears in Collections:||IJEB Vol.47(02) [February 2009]|
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