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Title: Synthesis of 1,5-benzothiazepines: Part XXXII - Synthesis and antimicrobial studies of 8-substituted-2,5-dihydro-2-(4-pyridyl)-4-(2-thienyl)-1,5-benzothiazepines
Authors: Pant, Seema
Chandra, Hem
Sharma, Priyanka
Pant, Umesh C
Keywords: 1,5-Benzothiazepines;Antibacterial;Antifungal;Heterocyclic
Issue Date: Jun-2006
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8 C07D
Abstract: The reactions of 5-substituted-2-aminobcnzenethiols, the substituents being F, CI, Br, CH3, OCH3 and OC2H5 4a-f, with an α, β-unsaturated heterocyclic ketone, 3-(4-pyridyl)-1-(2-thienyl)-2-propcnone, have been carried out in dry toluene containing piperidine. The products, 8-substituted-2, 5-dihydro-2-(4-pyridyl)-4-(2-thicnyl)-1,5-benzothiazepines, 5a-f, obtained in 65-70% yields, have been characterized by microestimations for C, H, N and JR, 1H NMR and mass spectral studies. The synthesized compounds have been screened for antimicrobial activity against the bacteria Escherichia coli and GPO and fungi, Aspergillus niger, Aspcrgillus flavus and Curvularia lunata. All the compounds show good antibacterial and antifungal activity.
Page(s): 1525-1530
ISSN: 0042-6075
Appears in Collections:IJC-B Vol.45B(06) [June 2006]

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