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|Title:||Synthesis of 1,5-benzothiazepines: Part XXXII - Synthesis and antimicrobial studies of 8-substituted-2,5-dihydro-2-(4-pyridyl)-4-(2-thienyl)-1,5-benzothiazepines|
Pant, Umesh C
|IPC Code:||Int. Cl.8 C07D|
|Abstract:||The reactions of 5-substituted-2-aminobcnzenethiols, the substituents being F, CI, Br, CH3, OCH3 and OC2H5 4a-f, with an α, β-unsaturated heterocyclic ketone, 3-(4-pyridyl)-1-(2-thienyl)-2-propcnone, have been carried out in dry toluene containing piperidine. The products, 8-substituted-2, 5-dihydro-2-(4-pyridyl)-4-(2-thicnyl)-1,5-benzothiazepines, 5a-f, obtained in 65-70% yields, have been characterized by microestimations for C, H, N and JR, 1H NMR and mass spectral studies. The synthesized compounds have been screened for antimicrobial activity against the bacteria Escherichia coli and GPO and fungi, Aspergillus niger, Aspcrgillus flavus and Curvularia lunata. All the compounds show good antibacterial and antifungal activity.|
|Appears in Collections:||IJC-B Vol.45B(06) [June 2006]|
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