Please use this identifier to cite or link to this item:
|Title:||One pot facile synthesis of 5-alkyl-1,2-dihydro-spiro[4H-3, 1-benzoxazine- 2,3'[3H]indol]-4,2'-diones under microwave irradiation|
Jain, Subhash C
|Keywords:||5-Alkyl-1,2-dihydro-spiro[4H-3, 1-benzoxazine-2,3'[3H]indol]-4,2'-diones;6-alkylanthranilic acids;Cyclocondensation;Microwave;Molecular modeling|
|IPC Code:||Int. CI.8 C07D|
|Abstract:||A facile synthesis of some novel 5-alkyl-1,2-dihydro-spiro[4H-3, 1-benzoxazine-2,3'[3H]indol]-4,2'-diones, in high yields, has been carried out classically as well as under microwave irradiation in solvent free conditions. Microwave irradiation offers tremendous advantages in the form of shorter reaction time, operational simplicity, cleaner reaction, easy work-up and better yields as compared to the classical method. Besides this, some novel 6-alkylanthranilic acids required for the synthesis of new spiro compounds have also been synthesized. The importance of alkyl substituent at C-6 position in anthranilic acid has been recognized again in such a cyclocondensation reaction, even when it is carried out under microwave irradiation. This is also supported by molecular modeling.|
|Appears in Collections:||IJC-B Vol.45B(06) [June 2006]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.