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Title: One pot facile synthesis of 5-alkyl-1,2-dihydro-spiro[4H-3, 1-benzoxazine- 2,3'[3H]indol]-4,2'-diones under microwave irradiation
Authors: Saxena, Anjali
Khanna, Pankaj
Bhagat, Sunita
Gupta, Archana
Jain, Subhash C
Keywords: 5-Alkyl-1,2-dihydro-spiro[4H-3, 1-benzoxazine-2,3'[3H]indol]-4,2'-diones;6-alkylanthranilic acids;Cyclocondensation;Microwave;Molecular modeling
Issue Date: Jun-2006
Publisher: NISCAIR-CSIR, India
IPC Code: Int. CI.8 C07D
Abstract: A facile synthesis of some novel 5-alkyl-1,2-dihydro-spiro[4H-3, 1-benzoxazine-2,3'[3H]indol]-4,2'-diones, in high yields, has been carried out classically as well as under microwave irradiation in solvent free conditions. Microwave irradiation offers tremendous advantages in the form of shorter reaction time, operational simplicity, cleaner reaction, easy work-up and better yields as compared to the classical method. Besides this, some novel 6-alkylanthranilic acids required for the synthesis of new spiro compounds have also been synthesized. The importance of alkyl substituent at C-6 position in anthranilic acid has been recognized again in such a cyclocondensation reaction, even when it is carried out under microwave irradiation. This is also supported by molecular modeling.
Page(s): 1504-1510
ISSN: 0042-6075
Appears in Collections:IJC-B Vol.45B(06) [June 2006]

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