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Title: Beneficial effects of modified egg* on oxidative stress in F₁- generation of metabolic syndrome-X induced Wistar rat
Authors: Taneja, Satish Kumar
Singh, Kshetrimatyum Birla
Keywords: Cu
Diabetes mellitus
Omega-3 fatty acids
Mg
Mn
Modified egg
Oxidative stress
Vitamin- E
Zn
Issue Date: Feb-2009
Publisher: CSIR
Abstract: Congenital malformations of neonates are one of the adverse effects of diabetic pregnancy which can be prevented by supplementation of vitamin E and C. The survived neonates usually are at higher risk to diabetes, hypertension, dyslipidemia and cardiovascular diseases that may possibly be prevented through antioxidants administration. In view of this information, the efficacy of modified poultry egg enriched with optimum minerals, vitamin E and omega-3 fatty acids was studied on F₁-generation, which were made to survive by feeding them this modified egg to diabetic mothers of Wistar rats. The survived F₁-generation displayed hyperglycemia, dyslipidemia and hypertension like their parents, evaluated after three months of the experiment. Their mineral status revealed a higher Zn and lower Cu, Mg and Mn levels in liver and kidney. Their lipid peroxidation products were however higher and the enzyme activities of superoxide dismutase, catalase, glutathione- S-transferase, glutathione reductase, glutathione (reduced) and glucose -6 phosphate dehydrogenase were significantly lower. In the other group of F₁-generation, fed modified egg mixed diet, a significant reduction in the blood pressure, serum glucose, serum lipid profile, and the lipid peroxidation products, and a significant increase in the activities of enzymes per se with reversal of Zn, Cu, Mg and Mn levels closer to the control group were recorded. The data suggest that the modified egg can ameliorate the oxidative stress in F₁- generation of diabetic rats by improving the mineral status in their body.
Page(s): 104-112
ISSN: 0019-5189
Source:IJEB Vol.47(02) [February 2009]

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