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Title: Synthesis, crystal structure, catecholase activity, DNA cleavage and anticancer activity of a dinuclear manganese(III)-bipyridine complex
Authors: Dey, Dhananjay
De, Abhranil
Pal, Sukanta
Mitra, Partha
Ranjani, Anandan
Gayathri, Loganathan
Chandraleka, Saravanan
Dhanasekaran, Dharumadurai
Akbarsha, Mohammad Abdulkadhar
Kole, Niranjan
Biswas, Bhaskar
Keywords: Coordination chemistry;Manganese;X-ray structure;Catecholase activity;DNA cleavage;Anticancer activity
Issue Date: 12-Feb-2015
Abstract: Design and synthesis of a dinuclear manganese(III) complex [Mn2(µ-O)(μ-O2CMe)2(H2O)2(2,2'-bipy)2](NO3)2.5H2O (1) [2,2'-bipy = 2,2'-bipyridine] with mono--oxo and di--acetato bridge has been reported. Single crystal X-ray diffraction study reveals that (1) crystallizes in monoclinic system with P21/n space group. Evaluation of (1) as a model system for the catechol oxidase enzyme by using 3,5-di-tert-butylcatechol (DTBC) as the substrate in methanol medium, reveals that the complex exhibits efficient catalytic activity with kcat value of 8.89×102. (1) cleaves the pBR 322 DNA without addition of an activating agent. Further, the anticancer activity of (1) on human hepatocarcinoma cell line (HepG2) has been examined. The apoptosis in the cell line has been assessed by the changes in cell morphology, which shows the efficacy of (1) to induce 55% of apoptotic for 24 h. Interestingly, the observed IC50 values reveal that (1) effects conformational change on DNA strongly and exhibits remarkable cytotoxicity.
Page(s): 170-178
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.54A(02) [February 2015]

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