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Title: Synthesis of novel N-aryl-3-dialkylamino-4-substituted maleimides
Authors: Patil, Nilesh S
Deshmukh, Ganesh B
Mahale, Keshao A
Gosavi, Kirankumar S
Patil, Sambhaji V
Keywords: Maleimide;Bromination;Acylation;Vilsmeier-Haack reaction;Enaminone
Issue Date: Feb-2015
Publisher: NISCAIR-CSIR, India
Abstract: The syntheses of several novel 3-dialkylamino-N-aryl-maleimides 3a-i and 6 are described via a conjugate elimination-addition-elimination pathway. Syntheses of their various 4-substituted derivatives 4a-i, 5a-c and 7-12 are also described. Introduction of a secondary amino group at C-3 position in N-arylmaleimides leads to the formation of enaminones 3a-i and 6, which undergo facile electrophilic substitutions at C-4 position in good to excellent yields to provide the highly functionalized maleimides 4a-i, 5a-c and 7-12.
Page(s): 272-278
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections: IJC-B Vol.54B(02) [February 2015]

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