Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/30535
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dc.contributor.authorPatel, Amit B-
dc.contributor.authorKumari, Premlata-
dc.contributor.authorChikhalia, Kishor H-
dc.date.accessioned2015-02-12T09:09:18Z-
dc.date.available2015-02-12T09:09:18Z-
dc.date.issued2015-02-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/30535-
dc.description260-271en_US
dc.description.abstractTo affiliate multiple bioactivities in a compact heteronuclei, two series of N-phenyl acetamides and thiazolidin-4-ones based quinazolines have been synthesized. The in vitro antimicrobial efficacy of the synthesized analogs has been assessed against two Gram-positive bacteria, six Gram-negative bacteria and four fungi. Furthermore, the final analogs have also been screened against Mycobacterium tuberculosis H37Rv in order to explore the antituberculosis activity. Results of the antimicrobial screening has shown that a majority of compounds exhibit significant antibacterial and noticeable antifungal activities, with minimum inhibitory concentrations 3.12–50 μg/mL against several microorganisms. Some of the synthesized analogs have also elicited noticeable inhibitory action against M. tuberculosis H37Rv strain. The best results are observed amongst the thiazolidinone substituted analogs. The structures of the synthesized analogs are corroborated on the basis of IR, 1H and 13C NMR, mass spectrometric and elemental analysis.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.54B(02) [February 2015]en_US
dc.subjectQuinazolineen_US
dc.subjectThiazolidin-4-oneen_US
dc.subjectPalladium-catalyzeden_US
dc.subjectAntibacterialen_US
dc.subjectAntifungalen_US
dc.subjectAntimycobacterialen_US
dc.titleExploring antimicrobial and antimycobacterial potential of novel quinazoline based thiazolidin-4-onesen_US
dc.typeArticleen_US
Appears in Collections: IJC-B Vol.54B(02) [February 2015]

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