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Title: Exploring antimicrobial and antimycobacterial potential of novel quinazoline based thiazolidin-4-ones
Authors: Patel, Amit B
Kumari, Premlata
Chikhalia, Kishor H
Keywords: Quinazoline;Thiazolidin-4-one;Palladium-catalyzed;Antibacterial;Antifungal;Antimycobacterial
Issue Date: Feb-2015
Publisher: NISCAIR-CSIR, India
Abstract: To affiliate multiple bioactivities in a compact heteronuclei, two series of N-phenyl acetamides and thiazolidin-4-ones based quinazolines have been synthesized. The in vitro antimicrobial efficacy of the synthesized analogs has been assessed against two Gram-positive bacteria, six Gram-negative bacteria and four fungi. Furthermore, the final analogs have also been screened against Mycobacterium tuberculosis H37Rv in order to explore the antituberculosis activity. Results of the antimicrobial screening has shown that a majority of compounds exhibit significant antibacterial and noticeable antifungal activities, with minimum inhibitory concentrations 3.12–50 μg/mL against several microorganisms. Some of the synthesized analogs have also elicited noticeable inhibitory action against M. tuberculosis H37Rv strain. The best results are observed amongst the thiazolidinone substituted analogs. The structures of the synthesized analogs are corroborated on the basis of IR, 1H and 13C NMR, mass spectrometric and elemental analysis.
Page(s): 260-271
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections: IJC-B Vol.54B(02) [February 2015]

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