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Title: Microwave-induced synthesis and anti-nemic activity of 4-amino-3- mercapto-5-pyridin-2-yl-4H-1,2,4-triazole Schiff bases
Authors: Mandal, Abhishek
Dutta, T K
Gupta, R L
Keywords: Schiff bases;Triazoles;Fusaric acid;Nematicide;Meloidogyne incognita;Rotylenchulus reniformis
Issue Date: Feb-2015
Publisher: NISCAIR-CSIR, India
Abstract: A series of twenty Schiff bases, 4-(benzylideneamino)-3-mercapto-5-pyridin-2-yl-4H-1,2,4-triazoles 6a-t, designed incorporating the picolinic acid moiety present in fusaric acid, a natural nematicide isolated from Fusarium oxysporum EF119, have been synthesized in MW-induced conditions and characterized using 1H and 13C NMR, FT-IR spectroscopy and elemental analysis. The Schiff bases obtained in high yields and screened for anti-nemic activity against Meloidogyne incognita and Rotylenchulus reniformis. Some of the test compounds show promising nematicidal and nematode repelling activity. 4-(4-Methoxybenzylideneamino)-3-mercapto-5-pyridin-2-yl-4H-1,2,4-triazole 6m, exhibits the highest nematicidal activity (LC50=218 g mL-1, M. incognita and 174 g mL-1, R. reniformis).
Page(s): 228-239
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections: IJC-B Vol.54B(02) [February 2015]

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