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|Title:||Challenges of Ionizing Radiation in Tumor Treatment and Role of Angiogenesis|
|Authors:||Das, Subir Kumar|
|Keywords:||Angiogenesis;Hypoxia;Ionizing radiation;Signaling mechanism;VEGF|
|Abstract:||Ionizing radiation is a non-specific, but most widely used therapeutic method for cancer treatment. However, a minor fraction of tumor cell population manages to survive after radiation. Radiation efficacy depends on adequate oxygen supply. Rapid growing tumors cause hypoxia that upregulates many pro-survival pathways. At clinical doses, radiation activates inflammatory pathways and causes oxidative stress that plays a positive role during angiogenesis. Selective targeting of signaling mechanisms may radiosensitize tumors.|
|ISSN:||0975-0959 (Online); 0301-1208 (Print)|
|Appears in Collections:|| IJBB Vol.51(6) [December 2014]|
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