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Title: Challenges of Ionizing Radiation in Tumor Treatment and Role of Angiogenesis
Authors: Das, Subir Kumar
Keywords: Angiogenesis;Hypoxia;Ionizing radiation;Signaling mechanism;VEGF
Issue Date: Dec-2014
Publisher: NISCAIR-CSIR, India
Abstract: Ionizing radiation is a non-specific, but most widely used therapeutic method for cancer treatment. However, a minor fraction of tumor cell population manages to survive after radiation. Radiation efficacy depends on adequate oxygen supply. Rapid growing tumors cause hypoxia that upregulates many pro-survival pathways. At clinical doses, radiation activates inflammatory pathways and causes oxidative stress that plays a positive role during angiogenesis. Selective targeting of signaling mechanisms may radiosensitize tumors.
Page(s): 527-530
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections: IJBB Vol.51(6) [December 2014]

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