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Title: Phospholipid Remodeling and Eicosanoid Signaling in Colon Cancer Cells
Authors: Das, Siddhartha
Martinez, Leobarda Robles
Ray, Suparna
Keywords: Colon cancer;Arachidonic acid;Lipid remodeling;Cyclooxygenase;Lipooxygenase;Prostaglandins;Leukotrienes
Issue Date: Dec-2014
Publisher: NISCAIR-CSIR, India
Abstract: Phospholipid remodeling and eicosanoid synthesis are central to lipid-based inflammatory reactions. Studies have revealed that membrane phospholipid remodeling by fatty acids through deacylation/reacylation reactions increases the risk of colorectal cancers (CRC) by allowing the cells to produce excess inflammatory eicosanoids, such as prostaglandins, thromboxanes and leukotrienes. Over the years, efforts have been made to understand the lipid remodeling pathways and to design anti-cancer drugs targeting the enzymes of eicosanoid biosynthesis. Here, we discuss the recent progress in phospholipid remodeling and eicosanoid biosynthesis in CRC.
Page(s): 512-519
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections: IJBB Vol.51(6) [December 2014]

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