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|Title:||Implications of Fundamental Signalling Alterations in Diabetes mellitus-associated Cardiovascular Disease|
|Keywords:||Diabetes mellitus;Signalling alterations;Cardiovascular disease pathology|
|Abstract:||The chronic diabetes mellitus (DM) is a major risk factor for cardiovascular disease. The incidence of cardiovascular disease might be a foremost cause of morbidity and mortality in patients afflicted with DM. In fact, DM is associated with multi-factorial cardiovascular signalling alterations via significant modulation of expression pattern, activation or release of PI3K, PKB, eNOS, EDRF, NADPH oxidase, EDHF, CGRP, adenosine, iNOS, ROCK, PKC-β2, CaMKII, microRNA (miR)-126 and miR-130a, which could result in inadequate maintenance of cardiovascular physiology and subsequent development of cardiovascular pathology. This review highlights the possible adverse implications of fundamental cardiovascular signalling alteration in DM-associated cardiovascular disease pathology.|
|ISSN:||0975-0959 (Online); 0301-1208 (Print)|
|Appears in Collections:|| IJBB Vol.51(6) [December 2014]|
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