Please use this identifier to cite or link to this item:
Title: Iterative ACORN as a high throughput tool in structural genomics
Authors: Selvanayagam, S
Velmurugan, D
Yamane, T
Keywords: ACORN;Congerin;Catalase
Issue Date: Aug-2006
Publisher: NISCAIR-CSIR, India
Abstract: High throughput macromolecular structure determination is very essential in structural genomics as the available number of sequence information far exceeds the number of available 3D structures. ACORN, a freely available resource in the CCP4 suite of programs is a comprehensive and efficient program for phasing in the determination of protein structures, when atomic resolution data are available. ACORN with the automatic model-building program ARP/wARP and refinement program REFMAC is a suitable combination for the high throughput structural genomics. ACORN can also be run with secondary structural elements like helices and sheets as inputs with high resolution data. In situations, where ACORN phasing is not sufficient for building the protein model, the fragments (incomplete model/dummy atoms) can again be used as a starting input. Iterative ACORN is proved to work efficiently in the subsequent model building stages in congerin (PDB-ID: lis3) and catalase (PDB-ID: 1gwe) for which models are available.
Page(s): 211-216
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.43(4) [August 2006]

Files in This Item:
File Description SizeFormat 
IJBB 43(4) 211-216.pdf1.19 MBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.