Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/30347
Title: Kinetic and physicochemical analysis of structurally different bis-pyridinium oximes against pesticide inhibited AChE
Authors: Sahu, Arvind Kumar
Gupta, Bhanushree
Sharma, Rahul
Singh, Yama
Musilek, Kamil
Kuca, Kamil
Ghosh, Kallol K
Keywords: Reactivators;Acetylcholinesterase;Paraoxon;Acid dissociation constant;Lipophilicity;Bis-pyridinium oximes
Issue Date: Jan-2015
Publisher: NISCAIR-CSIR, India
Abstract: Physicochemical properties such as acid dissociation constant, pKa, and lipophilicity, log P, of some bis-pyridinium monooximes with varying functionalities in the second pyridinium ring of the reactivator have been evaluated spectrophotometrically. In vitro reactivation kinetics of the investigated oximes against paraoxon inhibited electric eel AChE has been carried out. The studied oximes have pKa values within the range of 7.85−8.38 and negative log P values, exhibiting their low lipophilic character. Further, on the basis of reactivation parameters (kr, KD, kr2) the efficacy of bis-pyridinium monooximes has been explained.
Page(s): 40-45
URI: http://hdl.handle.net/123456789/30347
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.54A(01) [January 2015]

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