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Title: Synthesis of novel piperidino benzimidazole thiazolidinyl quinoline derivatives
Authors: Darsi, S S Praveen Kumar
Devi, B Rama
Naidu, A
Keywords: 2-Chloroquionoline-3-carboxaldehyde;2,4-thazoli-dinedione;-Proline;Knoevenagel condensation;2-(piperidino)-1H-benzoimidazole
Issue Date: Jan-2015
Publisher: NISCAIR-CSIR, India
Abstract: The synthesis of 5-((2-(4-(1H-benzoimidazol-2-yl)piperidino)-quinolin-3-yl)methylene)thiazolidine-2,4-dione 5a-c by the Knoevenagel condensation between 2-chloroquionoline-3-carboxaldehyde 1 with an active methylene group containing 2,4-thazolidinedione 2 in isopropyl alcohol using -proline as a catalyst followed by reaction with 2-(piperidino)-1H-benzoimidazole 3 in presence of triethylamine in THF is described. Alternatively, 5a-c were also synthesized from another reaction sequence 1 6 5.
Page(s): 142-145
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(01) [January 2015]

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