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|Title:||Synthesis of novel piperidino benzimidazole thiazolidinyl quinoline derivatives|
|Authors:||Darsi, S S Praveen Kumar|
Devi, B Rama
|Abstract:||The synthesis of 5-((2-(4-(1H-benzoimidazol-2-yl)piperidino)-quinolin-3-yl)methylene)thiazolidine-2,4-dione 5a-c by the Knoevenagel condensation between 2-chloroquionoline-3-carboxaldehyde 1 with an active methylene group containing 2,4-thazolidinedione 2 in isopropyl alcohol using -proline as a catalyst followed by reaction with 2-(piperidino)-1H-benzoimidazole 3 in presence of triethylamine in THF is described. Alternatively, 5a-c were also synthesized from another reaction sequence 1 6 5.|
|Appears in Collections:||IJC-B Vol.54B(01) [January 2015]|
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