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Title: Polyphosphoric acid catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by grinding under solvent-free conditions
Authors: Zhao, Ying
Zhao, Yongguang
Zhang, Jianping
Liu, Hongmei
Liang, Liman
Keywords: 3,4-Dihydropyrimidin-2(1H)-ones;Polyphosphoric acid;Synthesis;Solvent-free;Grinding method
Issue Date: Jan-2015
Publisher: NISCAIR-CSIR, India
Abstract: 3,4-Dihydropyrimidin-2-(1H)-ones have been obtained, in high yield, by grinding ternary mixture of different substituted aromatic aldehydes, ethyl acetoacetate and urea, in the presence of polyphosphoric acid, under solventless conditions. The facile reaction condition, simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.
Page(s): 139-141
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(01) [January 2015]

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