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Title: Green synthesis and antibacterial activity of 3-(3-aryl[1,8]naphthyridin-2-yl)-7-[1-[1,4-dioxo-1,2,3,4-tetrahydro-6-phthalazinyl]-2,2,2-trifluoro-1-(trifluoromethyl)ethyl]-2-(3-aryl [1,8]naphthyridin-2-yl)-1,2,3,4-tetrahydro-1,4-phthalazinediones
Authors: Mogilaiah, K
Rao, A Nageswara
Rao, P Koteswara
Keywords: 1,8-Naphthyridine;4,4′-(hexafluoroisopropylidene) diphthalic anhydride;Phthalazine;Microwave irradiation;Solid state;Grinding conditions;Antibacterial activity
Issue Date: Jan-2015
Publisher: NISCAIR-CSIR, India
Abstract: A simple and highly efficient procedure has been described for the synthesis of 3-(3-aryl[1,8]naphthyridin-2-yl)-7-[1-[1,4-dioxo-1, 2, 3, 4-tetrahydro-6-phthalazinyl]-2, 2, 2-trifluoro-1-(trifluoro-methyl)ethyl]-2-(3-aryl[1,8]naphthyridin-2-yl)-1,2,3,4-tetrahydro-1,4-phthalazinediones 3 by the condensation of 3-aryl-2-hydrazino-1,8-naphthyridines 1 with 4,4'-(hexafluoroiso-propylidene)diphthalic anhydride 2 in 2:1 molar ratio in the presence of catalytic amount of DMF under microwave irradiation/ in presence of catalytic amount of PTSA in the solid state at RT under grinding conditions. The products have been obtained in very good yields and in a state of high purity. The structures of the compounds 3 have been established on the basis of their spectral (IR and 1H NMR) and analytical data. The compounds 3 have been screened for their antibacterial activity.
Page(s): 135-138
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(01) [January 2015]

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