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Title: An efficient improved synthesis of carvedilol, via 2-(2-methoxyphenoxy)ethyl 4-methylbenzenesulfonate intermediate
Authors: Reddy, K Tatendra
Kumar, K Suneel
Omprakash, G
Dubey, P K
Keywords: Carvedilol;Impurity-B;2-(2-methoxyphenoxy)ethyl 4-methylbenzenesulfonate;β-amino alcohol;β-adrenergic blocking agent
Issue Date: Dec-2014
Publisher: NISCAIR-CSIR, India
Abstract: A facile synthesis of Carvedilol via a key 2-(2-methoxy-phenoxy)ethyl 4-methylbenzenesulfonate intermediate is described and this approach avoids the formation of bis side product (impurity-B) due to weak basic conditions and also operationally suitable for industrial application.
Page(s): 1615-1618
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.53B(12) December 2014]

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