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Title: Carbodiimide mediated synthesis of some novel 4-thiazolidinones and 2,4-disubstituted thiazoles bearing N-methyl tetrahydrocarbazole moiety
Authors: Gautam, Deepika
Chaudhary, R P
Keywords: 4-Thiazolidinones;Thiazoles;Grinding;DCC;DDQ;X-ray crystallography;Tetrahydrocarbazole
Issue Date: Dec-2014
Publisher: NISCAIR-CSIR, India
Abstract: 2,3-Dihydro-1H-carbazol-4(9H)-one, obtained from oxidation of tetrahydrocarbazole with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ), on reaction with N,N-dimethylformamide dimethyl acetal (DMF-DMA) affords 9-methyl-2,3-dihydro-1H-carbazol-4(9H)-one 3. The thiosemicarbazone derivative 4 of 9-methyl-2,3-dihydro-1H-carbazol-4(9H)-one on condensation with α-haloacids in presence of dicyclohexyl carbodiimide (DCC) furnish novel thiazolidin-4-ones 5 and on grinding with phenacyl bromides at room temperature produce new thiazole derivatives 6. The structure of all the synthesized compounds has been established by elemental analysis, IR, NMR and mass spectral data. X-Ray crystallographic studies of 2,3-dihydro-1H-carbazol-4(9H)-one 2 have been reported.
Page(s): 1606-1610
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.53B(12) December 2014]

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