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Title: In vitro binding of bile acid by apple pomace fibre and isabgol (Plantago ovata) fibre
Authors: Sharma, P C
Issar, K
Gupta, A
Keywords: In vitro;Binding;Apple fibre;Isabgol fibre;Hypocholesterolemic;Cholesterol
Issue Date: Dec-2014
Publisher: NISCAIR-CSIR, India
Abstract: In vitro binding studies of apple pomace fibre and isabgol (Plantago ovata) fibre were studied. Apple fibre exhibited higher (19.63 to 30.24%) in vitro binding properties to cholic and deoxycholic acid than that of isabgol fibre (17.20 to 22.20%) thereby indicating the superiority of apple fibre for its use in the development of hypocholesterolemic diets. The rate of adsorption increased with the increase in fibre contents, thus a linear relationship was observed for rate of adsorption. In vitro adsorption of cholic and deoxycholic acid to apple fibre found ranging between 10.86 to 22.19% as compared to 5.91 to 13.14% in isabgol fibre. The adsorption of bile acids to apple fibre was recorded to be the highest after 48 hrs of incubation. Besides these two bile acids, the adsorption of fibre to phosphate buffer was recorded to be the highest in isabgol fibre (9.83%) as compared to apple pomace fibre (8.39%). Thus, apple pomace fibre has better binding properties with deoxycholic acid against cholic acid than that of isabgol fibre and can be used in the formulation of diet with cholesterol lowering properties.
Page(s): 767-770
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.73(12) [December 2014]

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