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Title: Synthesis of some novel chalcones, pyrazolines, aminopyrimidines and their antimicrobial study
Authors: Solankee, Anjani
Patel, Rajnikant
Keywords: Chalcones;Acetyl pyrazolines;Aminopyrimidines;Antimicrobial activity
Issue Date: Nov-2014
Publisher: NISCAIR-CSIR, India
Abstract: Some new chalcones, 2,4 bis (tetrahydro-1,4-oxazine)-6-[4'-{3''-(substituted phenyl)-2''-propenon-1''-yl} phenyl amino]-s-triazine 6a-f have been achieved by the reaction between 2,4-bis-(tetrahydro-1,4-oxazine)-6-(4'-acetylphenylamino)-s-triazine 5 and different aromatic aldehydes, which on cyclisation with hydrazine hydrate in the presence of acetic acid give acetyl pyrazolines 7a-f. Chalcones 6a-f on cyclisation with guanidine hydrochloride in the presence of alkali give aminopyrimidines 8a-f. The characterization of newly synthesised compounds is based on IR, 1H NMR spectral data as well as elemental analysis. All the synthesised compounds have been screened for their antimicrobial activity.
Page(s): 1448-1453
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-B Vol.53B(11) [November 2014]

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