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Title: Probable mechanism(s) of antifungal activity of HA-2-91—A tetraene antibiotic
Authors: Naik, S R
Gupte, T E
Keywords: Antifungal action
Affinity for sterols
Reversible binding process
Issue Date: Jan-2009
Publisher: CSIR
Abstract: HA-2-91 (a tetraene antibiotic) is produced by Streptomyces arenae var. ukrainiana and shown to elicit antifungal activity (in vitro) against yeasts and filamentous fungi including plant pathogens and clinical isolates. Experimental studies were carried out by using both biological as well as chemical methods to understand the probable mechanism(s) of antifungal action of HA-2-91. Experimental findings suggest that HA-2-91 binds to both ergosterol and cholesterol present on the fungal and mammalian cell membranes. However, results showed preferential binding of HA-2-91 towards ergosterol than cholesterol. Further, the interactions (bindings of HA-2-91 with membrane sterols) seem to be reversible process. With such preferential degree of binding of HA-2-91, the effect will be greater on fungal cell membrane than mammalian cell membrane. Hence, adverse reactions like haemolysis may not occur.
Page(s): 91-96
ISSN: 0972-5849
Source: IJBT Vol.08(1) [January 2009]

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