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Title: Evaluation of anti-inflammatory activity of Dracaena cinnabari Balf. f. resin
Authors: Gupta, Deepika
Verma, Nandini
Das, Hasi R
Gupta, Rajinder K
Keywords: Dracaena cinnabari;Resin;Anti-inflammatory;LPS-stimulated macrophage;Rat paw edema;Homoisoflavan
Issue Date: Sep-2014
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2014.01)−A61K 36/00, A61P 29/00
Abstract: Dracaena cinnabari Balf. f. (Family- Dracaenaceae) resin is a traditional medicine since ancient times in many cultures. Most of the pharmacological investigations of this resin have been addressed to its anti-microbial, anti-viral and antioxidant activities. However, anti-inflammatory activity of D. cinnabari resin is not evaluated so far. The present study indicates that methanol extract of D. cinnabari resin (MEDC) and one of its components, 4'-hydroxy-7,8-methylenedioxyhomoisoflavan (MHF) inhibited nitrite, TNF-α and IL-6 productions in lipopolysaccharide-stimulated mouse macrophage cell line RAW 264.7 with increase in their concentrations. Anti-inflammatory activities of these treatments were further confirmed by the reduction of rat hind paw edema. These results suggest that MEDC and MHF have potential anti-inflammatory activity at the selected doses.
Page(s): 215-222
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.5(3) [September 2014]

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