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http://nopr.niscair.res.in/handle/123456789/29546| Title: | Evaluation of anti-inflammatory activity of Dracaena cinnabari Balf. f. resin |
| Authors: | Gupta, Deepika Verma, Nandini Das, Hasi R Gupta, Rajinder K |
| Keywords: | Dracaena cinnabari;Resin;Anti-inflammatory;LPS-stimulated macrophage;Rat paw edema;Homoisoflavan |
| Issue Date: | Sep-2014 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl. (2014.01)−A61K 36/00, A61P 29/00 |
| Abstract: | Dracaena cinnabari Balf. f. (Family- Dracaenaceae) resin is a traditional medicine since ancient times in many cultures. Most of the pharmacological investigations of this resin have been addressed to its anti-microbial, anti-viral and antioxidant activities. However, anti-inflammatory activity of D. cinnabari resin is not evaluated so far. The present study indicates that methanol extract of D. cinnabari resin (MEDC) and one of its components, 4'-hydroxy-7,8-methylenedioxyhomoisoflavan (MHF) inhibited nitrite, TNF-α and IL-6 productions in lipopolysaccharide-stimulated mouse macrophage cell line RAW 264.7 with increase in their concentrations. Anti-inflammatory activities of these treatments were further confirmed by the reduction of rat hind paw edema. These results suggest that MEDC and MHF have potential anti-inflammatory activity at the selected doses. |
| Page(s): | 215-222 |
| URI: | http://hdl.handle.net/123456789/29546 |
| ISSN: | 0976-0512 (Online); 0976-0504 (Print) |
| Appears in Collections: | IJNPR Vol.5(3) [September 2014] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJNPR 5(3) 215-222.pdf | 147.66 kB | Adobe PDF | View/Open |
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