Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/29473
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dc.contributor.authorRajanarendar, E-
dc.contributor.authorKishore, B-
dc.contributor.authorRamakrishna, S-
dc.contributor.authorNagaraju, D-
dc.contributor.authorVenkateshwarlu, P-
dc.date.accessioned2014-10-15T06:56:17Z-
dc.date.available2014-10-15T06:56:17Z-
dc.date.issued2014-10-
dc.identifier.issn0975-0975(Online); 0376-4710(Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/29473-
dc.description1275-1283en_US
dc.description.abstractSynthesis of novel isoxazolo[2'',3'':1',2']pyrimido[4',5':4,5]pyrimido[6,1-b]quinazoline-8-ones 6a-j, has been achieved by reaction of 5-amino-2-methyl-7-phenyl-7H-isoxazolo[2,3-a] pyrimidin-6-yl cyanides 4, with dimethyl formamide dimethylacetal followed by treatment with anthranilic acids in situ in one-pot. The key intermediate, viz., 5-amino-2-methyl-7-phenyl-7H-isoxazolo[2,3-a]pyrimidin-6-yl cyanide 4 is obtained by reaction of 3-amino-5-methyl isoxazole with aromatic aldehydes and malononitrile by a three-component one-pot process. The newly synthesized compounds 6a-j have been evaluated for their in vitro anticancer and antimicrobial activity. Compounds 6e and 6f exhibit potent anticancer and antimicrobial activity comparable to that of standard drugs.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.53B(10) [October 2014]en_US
dc.subjectIsoxazolo[2'',3'':1',2']pyrimido[4',5':4,5]pyrimido[6,1-b]quinazoline-8-onesen_US
dc.subjectOne-pot synthesisen_US
dc.subjectThree-component reactionen_US
dc.subjectAnticancer activityen_US
dc.subjectAntimicrobial activityen_US
dc.titleSynthesis of novel isoxazolo[2'',3'':1',2']pyrimido[4',5':4,5]pyrimido- [6,1-b]quinazoline-8-ones and their in vitro anticancer and antimicrobial activitiesen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.53B(10) [October 2014]

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