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|Title:||Synthesis of novel isoxazolo[2'',3'':1',2']pyrimido[4',5':4,5]pyrimido- [6,1-b]quinazoline-8-ones and their in vitro anticancer and antimicrobial activities|
|Keywords:||Isoxazolo[2'',3'':1',2']pyrimido[4',5':4,5]pyrimido[6,1-b]quinazoline-8-ones;One-pot synthesis;Three-component reaction;Anticancer activity;Antimicrobial activity|
|Abstract:||Synthesis of novel isoxazolo[2'',3'':1',2']pyrimido[4',5':4,5]pyrimido[6,1-b]quinazoline-8-ones 6a-j, has been achieved by reaction of 5-amino-2-methyl-7-phenyl-7H-isoxazolo[2,3-a] pyrimidin-6-yl cyanides 4, with dimethyl formamide dimethylacetal followed by treatment with anthranilic acids in situ in one-pot. The key intermediate, viz., 5-amino-2-methyl-7-phenyl-7H-isoxazolo[2,3-a]pyrimidin-6-yl cyanide 4 is obtained by reaction of 3-amino-5-methyl isoxazole with aromatic aldehydes and malononitrile by a three-component one-pot process. The newly synthesized compounds 6a-j have been evaluated for their in vitro anticancer and antimicrobial activity. Compounds 6e and 6f exhibit potent anticancer and antimicrobial activity comparable to that of standard drugs.|
|Appears in Collections:||IJC-B Vol.53B(10) [October 2014]|
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