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Title: Hypolipidemic and hypoglycemic effects of Centella asiatica (L.) extract in vitro and in vivo
Authors: Supkamonseni, Nattapon
Thinkratok, Aree
Meksuriyen, Duangdeun
Srisawat, Rungrudee
Keywords: Acarbose;Centella asiatica;Hypoglycemia;Hypolipidemia;Lipid emulsion-fed rat;Obesity;Orlistat;Rutin
Issue Date: Oct-2014
Publisher: NISCAIR-CSIR, India
Abstract: In vitro study revealed that pancreatic lipase inhibitory activity of C. asiatica extract was significantly higher than rutin but lower than orlistat, an anti-obesity drug. α-Amylase inhibitory activities of C. asiatica extract and rutin were significantly lower than acarbose, an anti-diabetic drug. Inhibition of α-glucosidase activity by C. asiatica extract, rutin, and acarbose was not different. The in vivo study substantiated the in vitro results. C. asiatica extract (1000 and 2000 mg/4 mL/kg), rutin (1000 mg/4 mL/kg), and orlistat (45 mg/4 mL/kg) significantly decreased plasma glucose, triglyceride and total cholesterol levels in lipid emulsion-induced hyperlipidemic rats at 3 h. However, plasma aspartate aminotransferase and alanine aminotransferase levels did not show significant change. The present work further supports that the C. asiatica extract and its bioactive rutin may help managing hypolipidemic and hypoglycemic effects.
Page(s): 965-971
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.52(10) [October 2014]

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