Please use this identifier to cite or link to this item:
http://nopr.niscair.res.in/handle/123456789/29439| Title: | Seabuckthron (Hippophae rhamnoides L.) leaf extract ameliorates the gamma radiation mediated DNA damage and hepatic alterations |
| Authors: | Khan, Amitava Manna, Krishnendu Chinchubose Das, Dipesh Kr Sinha, Mahuya Kesh, Swaraj Bandhu Das, Ujjal Dey, Rakhi Sharma Banerji, Asoke Dey, Sanjit |
| Keywords: | DNA damage;Gamma radiation;Hepatic alteration;Reactive oxygen species;Seabuckthron |
| Issue Date: | Oct-2014 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In vitro assessment showed that H. rhamnoides (HrLE) extract possessed free radical scavenging activities and can protect gamma (γ) radiation induced supercoiled DNA damage. For in vivo study, Swiss albino mice were administered with HrLE (30 mg/kg body weight) for 15 consecutive days before exposing them to a single dose of 5 Gy of γ radiation. HrLE significantly prevented the radiation induced genomic DNA damage indicated as a significant reduction in the comet parameters. The lipid peroxidation, liver function enzymes, expression of phosphorylated NFκB (p65) and IκBα increased whereas the endogenous antioxidants diminished upon radiation exposure compared to control. Pretreatment of HrLE extract ameliorated these changes. Based on the present results it can be concluded that H. rhamnoides possess a potential preventive element in planned and accidental nuclear exposures. |
| Page(s): | 952-964 |
| URI: | http://hdl.handle.net/123456789/29439 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.52(10) [October 2014] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 52(10) 952-964.pdf | 639.72 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.