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Title: Seabuckthron (Hippophae rhamnoides L.) leaf extract ameliorates the gamma radiation mediated DNA damage and hepatic alterations
Authors: Khan, Amitava
Manna, Krishnendu
Das, Dipesh Kr
Sinha, Mahuya
Kesh, Swaraj Bandhu
Das, Ujjal
Dey, Rakhi Sharma
Banerji, Asoke
Dey, Sanjit
Keywords: DNA damage;Gamma radiation;Hepatic alteration;Reactive oxygen species;Seabuckthron
Issue Date: Oct-2014
Publisher: NISCAIR-CSIR, India
Abstract: In vitro assessment showed that H. rhamnoides (HrLE) extract possessed free radical scavenging activities and can protect gamma (γ) radiation induced supercoiled DNA damage. For in vivo study, Swiss albino mice were administered with HrLE (30 mg/kg body weight) for 15 consecutive days before exposing them to a single dose of 5 Gy of γ radiation. HrLE significantly prevented the radiation induced genomic DNA damage indicated as a significant reduction in the comet parameters. The lipid peroxidation, liver function enzymes, expression of phosphorylated NFκB (p65) and IκBα increased whereas the endogenous antioxidants diminished upon radiation exposure compared to control. Pretreatment of HrLE extract ameliorated these changes. Based on the present results it can be concluded that H. rhamnoides possess a potential preventive element in planned and accidental nuclear exposures.
Page(s): 952-964
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.52(10) [October 2014]

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