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Title: Development of dog mammary tumor xenograft in immunosuppressed Swiss albino mice
Authors: Rajmani, R S
Singh, Prafull Kumar
Kumar, Sanjay
Kumar, G Ravi
Sahoo, Aditya P
Santra, Lakshman
Saxena, Shikha
Singh, Lakshya Veer
Chaturvedi, Uttara
Saxena, Lovleen
Desai, G S
Gupta, Shishir Kumar
Kumar, Amit
Jadon, N S
Tiwari, Ashok K
Keywords: Dog mammary tumour;Immunosuppression;Xenograft
Issue Date: Oct-2014
Publisher: NISCAIR-CSIR, India
Abstract: Development and study of dog mammary tumour xenograft in immunosuppressed Swiss Albino Mice adds a new dimension in cancer research as dog tumors have many similarities with human tumors regarding progression, histopathology, molecular mechanism, immune response and therapy. Failure of the immune system to recognize and eliminate cancer cells leads to cancer progression and the fight between immune cells and cancer cells has a great role in understanding the mechanism of cancer progression and elimination. Rejection and acceptance of tumour xenograft depends on efficiency of CD4+, CD8+ and NK cell populations. In the present investigation, dog mammary tumor xenograft in cyclosporine-A and γ-irradiated, immunosuppressed Swiss Albino mice was developed and the immune cell status of graft accepted and rejected mice was assessed. It was observed that all the major immune cells (CD4+, CD8+ and NK cells) play an equal role in tumour rejection.
Page(s): 935-942
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.52(10) [October 2014]

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