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http://nopr.niscair.res.in/handle/123456789/2941
Title: | Synthesis and in vitro study of biological activity of heterocyclic N-Mannich bases |
Authors: | Shah, T B Gupte, A Patel, M R Chaudhari, V S Patel, H Patel, V C |
Keywords: | Biginelli reaction;dihydropyrimidones;N-Mannich bases;antimicrobial activity |
Issue Date: | Jan-2009 |
Publisher: | CSIR |
Abstract: | Three series of N-Mannich bases of 3,4-dihydropyrimidine-2(1H)-ones(DHPMs) 7a-g, 8a-g, and 9a-g have been prepared by Mannich reaction of DHPMs 4a-c with seven different heterocyclic secondary amino compounds 6a-g and formaldehyde 5. The precursors DHPMs 4a-c have been derived by a Biginelli reaction of three aromatic aldehydes 1a-c with ethylacetoacetate 2 and urea 3. The chemical structure of all the three series of N-Mannich bases have been elucidated by elemental analysis and spectral studies (IR, ¹H and ¹³C NMR). They have been assayed in vitro for their biological activity against E. coli and B. subtilis bacterial species and A. niger and C. albicans fungal microorganisms. |
Page(s): | 88-96 |
URI: | http://hdl.handle.net/123456789/2941 |
ISSN: | 0376-4699 |
Appears in Collections: | IJC-B Vol.48B(01) [January 2009] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 48B(1) 88-96.pdf | 172.79 kB | Adobe PDF | View/Open |
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