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Title: A facile synthesis of 3-hydroxy-N-(4-oxo-2-arylthiazolidin-3-yl)quinoxaline-2-carboxamides and N-(3-chloro-2-oxo-4-arylazetidin-1-yl)-3-hydroxyquinoxaline-2-carboxamides
Authors: Haripriya, V
Laxminarayana, E
Chary, M Thirumala
Keywords: Quinoxaline;Phenylenediamine;Arylidine;Azetidinone;Thiazolidinone
Issue Date: Sep-2014
Publisher: NISCAIR-CSIR, India
Abstract: o-Phenylenediamine reacts with diethylbromo malonate to form ethyl-1,2,3,4-tetrahydro-3-oxoquinoxaline-2-carboxylate 2, which reacts with hydrazinehydrate to form 3-hydroxy-quinoxaline-2-carbohydrazide 3. Compound 3 on condensation with different aromatic aldehydes gives N'-arylidene-3-hydroxyquinoxaline-2-carbohydrazides 4 which is cyclised with chloroacetyl chloride and thioglycolic acid to obtain N-(3-chloro-2-oxo-4-arylazetidin-1-yl)-3-hydroxyquinoxaline-2-carboxamides 5 and 3-hydroxy-N-(4-oxo-2-phenylthiazolidin-3-yl)quinoxaline-2-carboxamides 6 respectively. The structures of these compounds are confirmed by 1H NMR and LC-MS data.
Page(s): 1222-1225
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-B Vol.53B(09) [September 2014]

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