|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(01) [January 2009] >
| Title: | Tungstate-catalyzed oxidation of triptans with hydrogen peroxide: A novel method for the synthesis of N,N- dimethyltryptamine N-oxides |
| Authors: | Ray, Purna Chandra
Mittapelli, Vasantha
Chauhan, Yogendra Kumar
Konudula, Babu Rao
Tyagi, Om Dutt |
| Keywords: | Sodium tungstate
Sumatriptan N-oxide
Rizatriptan N-oxide
Zolmitriptan N-oxide
Almotriptan-N-oxide |
| Issue Date: | Jan-2009 |
| Publisher: | CSIR |
| Abstract: | A straight forward oxidation method of triptans have been described for the synthesis of N,N-dimethyl-2-[5-[substituted-1H-indole-3-yl]ethanamine-N-oxides using sodium tungstate and 30% aqueous hydrogen peroxide solution in the presence of methanesulphonic acid. The significance of the process is its simplicity and efficiency in isolating the triptan N-oxide derivatives as free base and as malate salt. |
| Page(s): | 134-136 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.48B(01) [January 2009]
|
|
