Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/29367
Title: Simple method for synthesis of isolated heterocyclic compounds incorporating 2-(2-bromoacetyl)isoindoline-1,3-dione and 2-(2-cyanoacetyl)isoindoline-1,3-dione
Authors: Azab, Islam Helmy El
Rady, Eman Abd El
Keywords: 2-Acetylisoindoline-1,3-dione;3-(1,3-dioxoisoindolin-2-yl)-3-oxopropanenitrile;2-(2-bromoacetyl)isoindoline-1,3-dione;β-lactam, thiazolidin-4-ones
Issue Date: Sep-2014
Publisher: NISCAIR-CSIR, India
Abstract: 2-(2-Bromoacetyl)isoindoline-1,3-dione 2 and 2-(2-cyanoacetyl)isoindoline-1,3-dione 3 have been used as starting intermediates for synthesis of functionalized heterocyclic derivatives such as, 2-(2-aminothiazol-5-yl)isoindoline-1,3-dione 4, 2-(2-(benzylideneamino)thiazol-5-yl)isoindoline-1,3-dione 5, 2-(2-(3-chloro-2-oxo-4-phenylazetidin-1-yl)thiazol-5-yl)isoindoline-1,3-dione 6, 2-(2-(4-oxo-2-phenylthiazolidin-3-yl)thiazol-5-yl)isoindoline-1,3-dione 7, 2-(2-arylhydrazono)-2-bromo(cyano)acetyl)-isoindoline-1,3-dione 8, 6-bromo-5-(1,3-dioxoisoindolin-2-yl)-3-oxo-2-phenyl-2,3-dihydropyridazine- 4-carbonitrile 10a, 4-(1,3-dioxoisoindolin-2-yl)-6-oxo-1-phenyl-1,6-dihydropyridazine-3,5-dicarbonitrile 10b, 1-acetyl-3-(1,3-dioxoisoindolin-2-yl)-5-aryl-4,5-dihydro-1H-pyrazole-4-carbonitrile 12, 4-cyano-3-(1,3-dioxoisoindolin-2-yl)-5-aryl-4,5-dihydro-1H-pyrazole-1-carbothioamide 13, 3-(1,3-dioxoisoindolin-2-yl)-1-(4-oxo-4,5-dihydrothiazol-2-yl)-5-phenyl-4,5-dihydro-1H-pyrazole-4-carbonitrile 14, 3-(1,3-dioxoisoindolin-2-yl)-1-(5-(1,3-dioxoisoindolin-2-yl)thiazol-2-yl)-5-phenyl-4,5-dihydro-1H-pyrazole-4-carbonitrile 15, 2-(3-amino-5-(phenylamino)-1H-pyrazole-4-carbonyl)isoindoline-1,3-dione 17, 2-(5,7-dimethyl-2-(phenyl-amino)pyrazolo[1,5-a]pyrimidine-3-carbonyl)isoindoline-1,3-dione 18 and 2-(7-phenyl-2-(phenyl-amino)pyrazolo[1,5-a]pyrimidine-3-carbonyl)isoindoline-1,3-dione 20. The synthesized compounds have been characterized by IR, MS, 1H NMR and 13C NMR spectral analy­sis.
Page(s): 1194-1204
URI: http://hdl.handle.net/123456789/29367
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-B Vol.53B(09) [September 2014]

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