Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/29363
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dc.contributor.authorDesai, N C-
dc.contributor.authorKotadiya, G M-
dc.date.accessioned2014-09-15T05:31:18Z-
dc.date.available2014-09-15T05:31:18Z-
dc.date.issued2014-09-
dc.identifier.issn0975-0975(Online); 0376-4710(Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/29363-
dc.description1159-1168en_US
dc.description.abstractIn the present communication, a series of novel 1-(2-(3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-3-(aryl)prop-2-en-1-ones 5a-o have been efficiently synthesized and evaluated for their in vitro antimicrobial and cytotoxic activities. The results of antimicrobial study reveal the compounds 5f, 5g and 5k-m to be among the most potent antimicrobial agents compared to the standard drugs chloramphenicol and griseofulvin. From the standpoint of SAR studies, it is observed that presence of electron donating groups remarkably enhanced the antimicrobial activity of newly synthesized compounds. Further, the results of preliminary MTT cytotoxicity studies on HeLa cells suggest that the potent antimicrobial activity of 5f, 5g and 5k-m is accompanied by low cytotoxicity. All the newly synthesized analogues have been characterized by IR, 1H and 13C NMR and mass spectroscopic techniques. en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.53B(09) [September 2014]en_US
dc.subjectAntimicrobial activityen_US
dc.subjectCytotoxicityen_US
dc.subjectPyrazoleen_US
dc.subject1,3,4-oxadiazoleen_US
dc.subjectPyridineen_US
dc.titleSynthesis, antimicrobial and cytotoxic activity of pyrazole derivatives of pyridyloxadiazolesen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.53B(09) [September 2014]

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