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Title: Microwave assisted sp3 C-H activation of 2-methyl-quinoline and addition to electron deficient ketones
Authors: Rao, Nalajala Nageswara
Mali, Prakash Rambhau
Meshram, H M
Keywords: Catalyst-free;Ketone;Microwave;2-methyl-quinoline;Water
Issue Date: Sep-2014
Publisher: NISCAIR-CSIR, India
Abstract: A catalyst-free aqueous mediated nucleophilic addition of 2-methyl-quinolines with various ketones has been performed under microwave irradiation. The substrates α,β-unsaturated ketones and diketones on reaction with methyl aza-arenes give selectively, 1,2-addition and mono addition products respectively with good yields. A significant improvement in this protocol is isatin which gives 3-substituted-3-hydroxy substituted product instead of bis(quinolin-2-ylmethyl) indolin-2-one derivatives. The whole protocol fulfils the principle of green chemistry and sustainability, minimizing the use of organic solvents and generation of any type of wastes.
Page(s): 1153-1158
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-B Vol.53B(09) [September 2014]

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