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Title: | Synthesis and antimicrobial screening of 5-benzylidine-2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one and its derivatives |
Authors: | Mulwad, Vinata V Mir, Abid Ali Parmar, Hitesh T |
Keywords: | Aminocoumarin;Iminothiazolidinone;4-thiazolidin-one;Aromatic aldehydes;Antimicrobial activity |
Issue Date: | Jan-2009 |
Publisher: | CSIR |
Abstract: | 2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one 4a-c have been synthesized from 6-amino-coumarin as starting material. Condensation of iminothiazolidinone with different substituted aromatic aldehydes occurred at reactive methylene group present at C-5 position of thiazolidin-4-one ring and resulted in the formation of 5-arylidene-2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one 5a-i. The formation of 2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one 4c was confirmed by hydrolysis with 2% HCl to give 3-(2-oxo-2H-benzopyran-6-yl)-thiazolidine-2,4-dione 6c. The structures of the compounds 2a-c, 4a-c, 5a-i and 6c have been established on the basis of spectral and analytical data. The compounds 5a-i has been screened for their antimicrobial activity and has been found to exhibit significant antibacterial activities. |
Page(s): | 137-141 |
URI: | http://hdl.handle.net/123456789/2933 |
ISSN: | 0376-4699 |
Appears in Collections: | IJC-B Vol.48B(01) [January 2009] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 48B(1) 137-141.pdf | 80.89 kB | Adobe PDF | View/Open |
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