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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(01) [January 2009] >
| Title: | Synthesis and antimicrobial screening of 5-benzylidine-2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one and its derivatives |
| Authors: | Mulwad, Vinata V
Mir, Abid Ali
Parmar, Hitesh T |
| Keywords: | Aminocoumarin
Iminothiazolidinone
4-thiazolidin-one
Aromatic aldehydes
Antimicrobial activity |
| Issue Date: | Jan-2009 |
| Publisher: | CSIR |
| Abstract: | 2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one
4a-c have been synthesized from 6-amino-coumarin as starting material. Condensation of iminothiazolidinone with different substituted aromatic aldehydes occurred at reactive methylene group present at C-5 position of thiazolidin-4-one ring and resulted in the formation of 5-arylidene-2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one 5a-i. The formation of 2-imino-3-(2-oxo-2H-benzopyran-6-yl)-thiazolidin-4-one 4c was confirmed by hydrolysis with 2% HCl to give 3-(2-oxo-2H-benzopyran-6-yl)-thiazolidine-2,4-dione 6c. The structures of the compounds 2a-c, 4a-c, 5a-i and 6c have been established on the basis of spectral and analytical data. The compounds 5a-i has been screened for their antimicrobial activity and has been found to exhibit significant antibacterial activities. |
| Page(s): | 137-141 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.48B(01) [January 2009]
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