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|Title:||Conformational studies of nonapeptide using NMR|
|Abstract:||The present study describes the study of conformation of nonapeptide Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val (YMDGTMSQV), capable of being recognized by melanoma specific T-cells, corresponds to residue 369 to 377 of tyrosenase gene. Secondary structures have been obtained by ¹H NMR and molecular dynamic simulation using CSI values, 2D COSY, NOESY and ROESY, at 500 and 600 MHz in solvent DMSO-d₆. On this basis, nonapeptide shows a ϒ bend and non-ideal type 1 β-turn.|
|Appears in Collections:|| IJC-B Vol.48B(01) [January 2009]|
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