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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(01) [January 2009] >
| Title: | Conformational studies of nonapeptide using NMR |
| Authors: | Tripathi, Jalaj
Desai, Prashant
Srivastava, Sudha
Cuthino, Evans |
| Keywords: | NMR data
Nona peptide
Melanoma
Epitope
ϒ bend
Non-ideal β-turn |
| Issue Date: | Jan-2009 |
| Publisher: | CSIR |
| Abstract: | The present study describes the study of conformation of nonapeptide Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val (YMDGTMSQV), capable of being recognized by melanoma specific T-cells, corresponds to residue 369 to 377 of tyrosenase gene. Secondary structures have been obtained by ¹H NMR and molecular dynamic simulation using CSI values, 2D COSY, NOESY and ROESY, at 500 and 600 MHz in solvent DMSO-d₆. On this basis, nonapeptide shows a ϒ bend and non-ideal type 1 β-turn. |
| Page(s): | 103-109 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.48B(01) [January 2009]
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