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IJC-B Vol.48B(01) [January 2009] >


Title: Conformational studies of nonapeptide using NMR
Authors: Tripathi, Jalaj
Desai, Prashant
Srivastava, Sudha
Cuthino, Evans
Keywords: NMR data
Nona peptide
Melanoma
Epitope
ϒ bend
Non-ideal β-turn
Issue Date: Jan-2009
Publisher: CSIR
Abstract: The present study describes the study of conformation of nonapeptide Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val (YMDGTMSQV), capable of being recognized by melanoma specific T-cells, corresponds to residue 369 to 377 of tyrosenase gene. Secondary structures have been obtained by ¹H NMR and molecular dynamic simulation using CSI values, 2D COSY, NOESY and ROESY, at 500 and 600 MHz in solvent DMSO-d₆. On this basis, nonapeptide shows a ϒ bend and non-ideal type 1 β-turn.
Page(s): 103-109
ISSN: 0376-4699
Source: IJC-B Vol.48B(01) [January 2009]

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