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Title: In vitro antioxidant studies on diselenodinicotinamide: A potent GPx mimic
Authors: Parashiva, Prabhu C
Adhikari, B
Phadnis, P P
Chakraborty, S
Jain, V K
Priyadarsini, K I
Keywords: Bioinorganic chemistry;Diselenodinicotinamide;Selenium;Antioxidant activity;Glutathione peroxidase
Issue Date: Jul-2014
Publisher: NISCAIR-CSIR, India
Abstract: Multifunctional  biological  activities  of  a  glutathione  peroxidase  mimic, diselenodinicotinamide  (2, 2′-diselenobis- [3-amidopyridine]) (SNA), as an antioxidant are evaluated for its ability to inhibit free radical induced damage to biomolecules like lipids and DNA. Damage to lipids has been assayed by lipid peroxidation and DNA damage by gel-electrophoresis using AAPH or γ-radiation induced damage. The results indicate that SNA, at micro-molar concentration, protects both lipids and DNA from AAPH and γ-radiation induced damage. Also, SNA is non-toxic to normal cells but slightly toxic to cancer cells. These results coupled with its water solubility and GPx mimicking activity make SNA a potential candidate for future in vivo studies as an antioxidant.
Page(s): 781-786
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.53A(07) [July 2014]

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