Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/29045
Title: Anti-hyperglycemic activity of Rutin in streptozotocin-induced diabetic rats: An effect mediated through cytokines, antioxidants and lipid biomarkers
Authors: Niture, Netaji T
Ansari, Ansar A
Naik, Suresh R
Keywords: Antidiabetic activity;Antioxidants;Lipid profile;Pro-inflammatory cytokines;Rutin;Streptozotocin
Issue Date: Jul-2014
Publisher: NISCAIR-CSIR, India
Abstract: Administration of rutin (50 and 100 mg/kg) and pioglitazone (10 mg/kg) orally for 3 weeks treatment significantly improved body weight, reduced plasma glucose and glycosylated hemoglobin, pro-inflammatory cytokines (IL-6 and TNF-α), restored the depleted liver antioxidant status and serum lipid profile in high fat diet + streptozotocin induced type 2 diabetic rats. Rutin treatment also improved histo-architecture of ß islets and reversed hypertrophy of hepatocytes. Rutin exhibited significant antidiabetic activity, presumably by inhibiting inflammatory cytokines, improving antioxidant and plasma lipid profiles in High fat diet + streptozotocin induced type 2 diabetic model and may be useful as a diabetic modulator along with standard antidiabetic drugs. However, such effects need to be confirmed on human subjects in clinical condition.
Page(s): 720-727
URI: http://hdl.handle.net/123456789/29045
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.52(07) [July 2014]

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