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|Title:||Phenol-amide chelates of iron (III) as catalysts for hydrolysis of active esters|
Pradhan, Guru C
Dash, Anadi C
|Abstract:||The hydrolysis of p-nitrophenylacetate has been studied in the presence of mononuclear iron(III) chelates of 1,2-bis(2- hydroxybenzamido)ethane(I), 1 ,3-bis(2-hydroxybenzamido)propane(II), 1 ,5-bis(2-hydroxybenzamido )-3-aza-pentane(III), and 1,8-bis(hydroxybenzamido)-3,6-diazaoctane(IV) in 10 % (v/v) MeOH +H2O medium at pH = 8.3 - 9.5 (borate buffer), 26.5 ± 0.2°C, and l = 0.1 mol dm-3. The amide NH-deprotonated chelate of I has been found to be the most effective catalyst. Catalysis is attributed to both FeIII - OH and Fe III N(CO)R moieties of this chelate. The catalytic efficiency decreases with chelate ring expansion and the steric effects of the multidenate ligands. The results further indicate that the metal-bound amide function and its deprotonated form are of much reduced activity as compared to metal-bound hydroxo group.|
|Appears in Collections:||IJC-A Vol.41A(03) [March 2002]|
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