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IJEB Vol.47(01) [January 2009] >


Title: Protective effect of Withaferin-A on tumour formation in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis in hamsters
Authors: Manoharan, S
Panjamurthy, K
Menon, Venugopal P
Balakrishnan, S
Alias, Linsa Mary
Keywords: Antioxidants
Detoxication agents
Lipid peroxidation
Oral cancer
Withaferin-A
Issue Date: Jan-2009
Publisher: CSIR
Abstract: With an aim to investigate the protective effect of Withaferin-A on 7,12-dimethylbenz[a]anthracene (DMBA) induced oral carcinogenesis in Syrian golden hamsters, tumour incidence, tumour volume and tumour burden and status of detoxication agents, lipid peroxidation and antioxidants in DMBA administered (3 times/week for 14 weeks) hamsters were assessed. Hundred percent tumour formation in DMBA alone administered animal was observed. Oral administration of Withaferin-A (20 mg/kg body weight) to DMBA administered animals for 14 weeks completely prevented the tumour incidence, tumour volume and tumour burden. Also, Withaferin-A showed significant anti-lipid peroxidative and antioxidant properties and maintained the status of phase-I and phase-II detoxication agents during DMBA-induced oral carcinogenesis. The results thus indicate that the protective effect of Withaferin-A is probably due to its anti-lipid peroxidative and antioxidant functions as well as modulating effect on carcinogen detoxication during DMBA-induced oral carcinogenesis.
Page(s): 16-23
ISSN: 0019-5189
Source:IJEB Vol.47(01) [January 2009]

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