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Title: Antioxidant flavone glycosides and other constituents from Premna latifolia leaves
Authors: Ghosh, Partha Sarathi
Das, Niranjan
Dinda, Biswanath
Keywords: Premna latifolia;Verbenaceae;Flavonoids;Antioxidant
Issue Date: Jun-2014
Publisher: NISCAIR-CSIR, India
Abstract: A new flavone glycoside, apigenin 7-O---apiofuranosyl (12)---rhamnopyranoside 1 along with known compounds, apigenin 7-O---glucopyranoside-4'-acetate 2 and -sitosterol-3-O---glucoside 3 have been isolated from the MeOH extract of the leaves of the medicinal plant, Premna latifolia Roxb (Verbenaceae). The structure of the new compound 1 has been elucidated on the basis of detailed spectral (including 2D-NMR) and chemical (including transformations into hexa and hepta acetates) studies. The notations of sugars in 1 have been assigned on GC analysis of their TMS derivatives. The isolation of compound 2 is being reported for the first time from a higher plant. Both flavones 1 and 2 exhibit significant DPPH radical scavenging activity with IC50 value of 16.0 and 22.5 μg/mL, respectively, which is comparable to that of standard antioxidant, BHT (IC50 of 17.5 μg/mL). Hence, the MeOH extract of the leaves of this plant may be useful as a potential source of natural antioxidant.
Page(s): 746-749
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.53B(06) [June 2014]

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