Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/2891
Title: Cardioprotective effect of lipistat against doxorubicin induced myocardial toxicity in albino rats
Authors: Koti, B C
Vishwanathswamy, A H M
Wagawade, Jyoti
Thippeswamy, A H M
Keywords: Antioxidant
Cardiotoxicity
Doxorubicin
Lipistat
Issue Date: Jan-2009
Publisher: CSIR
Abstract: Preventive role of lipistat against doxorubicin induced myocardial toxicity in rats has been reported.. Cardiotoxicity was produced by doxorubicin administration (15 mg/kg for 2 weeks). Lipistat (350 mg/kg, orally) was administered as pretreatment for 2 weeks and then for 2 weeks alternated with doxorubicin. The general observations, mortality, histopathology, biomarker enzymes like lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), serum lipid profiles like total cholesterol, triglycerides, low-density lipoprotein (LDL) and high-density lipoprotein (HDL), antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were monitored after 3 weeks of last dose. Pretreatment with the lipistat significantly protected myocardium from the toxic effects of doxorubicin by reducing the elevated level of biomarker enzymes like LDH and CPK to the normal and serum lipids such as total cholesterol, triglyceride and LDL back to normal. Lipistat increases the decreased level of GSH, SOD and CAT and decreases the increased level of malondialdehyde in cardiac tissue. The repeated administration of doxorubicin causes cardiomyopathy associated with an antioxidant deficit and increased level of lipid profiles by interfering with fatty acid metabolism. The results support the lipid lowering and antioxidant properties of lipistat, which indicate the cardioprotective property against doxorubicin induced cardiotoxicity.
Description: 41-46
URI: http://hdl.handle.net/123456789/2891
ISSN: 0019-5189
Appears in Collections:IJEB Vol.47(01) [January 2009]

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